Work

Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1

Year: 2022

Type: article

Source: Nature Chemical Biology

DOI: 10.1038/s41589-022-01048-w

Authors: Zhiping Feng, Marisa E. Hom, Thomas E. Bearrood, Zachary C. Rosenthal, Daniel Fernández, Alison E. Ondrus, Yuchao Gu, Aaron K. McCormick, Madeline G. Tomaske, Cody R. Marshall, Toni Kline, Che-Hong Chen, Daria Mochly-Rosen, Calvin J. Kuo, James K. Chen

Institutions: Stanford University, Vanderbilt University, Vanderbilt University Medical Center, University of Illinois Chicago, Stanford Medicine, Stanford Cancer Institute

Language: English

Topic: Enzyme function and inhibition

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Energy, U.S. Department of Health and Human Services, Weston Havens Foundation, Emerson Collective, National Institutes of Health, Office of Science, Stand Up To Cancer, National Institute on Alcohol Abuse and Alcoholism, National Cancer Institute, National Institute of General Medical Sciences, Basic Energy Sciences, Biological and Environmental Research, Stanford Cancer Institute, SLAC National Accelerator Laboratory

Awards: G1229526393, G1286251239, 30-parameter FACSymphony A3 flow cytometer for Shared Resource Lab, G1332629412, BAY AREA & ANDERSON TEAM AGAINST ACQUIRED RESISTANCE - U54 PROGRAM (BAATAAR-UP), G1672651436, G1692178206, G1831385526, G203043384, G2300450775, G2371548206, G262532246, G2649945114, Targeting colorectal cancer stem cells with ALDH1B1 antagonists, G303061748, Ethanol and aldehyde dehydrogenases in health and disease, G315621713, Chemical tools for developmental biology, G3331839173, G3552386868, G3741462800, 500 MHz NMR Spectrometer System with High Sensitivity Cryoprobe and Automated Sample Changer for Biochemical Research, G4235786860, A Modern Flexible Mass Spectrometry Platform for Advancing Proteomics Research, G4761179605, Development of Gli1-Selective Therapeutics for Hedgehog Pathway-Dependent Cancers, Gli1-selective inhibitors of the Hedgehog signaling pathway, G495301720, G498139845, G5503912071, G5570207115, G5588004637, G634220122, G6442706522, G6550344761, G6674189921, G7283024673, G764404303, A Synchroton Radiation Structural Biology Resource, G8101849948, Organoid-based Discovery of Oncogenic Drivers and Treatment Resistance Mechanisms, G8351389279, G8382000481, G8685501887, G8866651128, G8925327636, G9000069621, G9000216902, G9000262446, G9000305324, G9000309862, G9000346532, Stanford Cancer Institute, G911061179, G969889393

OpenAlex ID: W4283820098

FWCI: 3.519

Cites: 60

Cited by: 60

Related to: 10