Work

Synthesis of Thiazolidinedione Compound Library

Year: 2022

Type: article

Abstract: Thiazolidinediones (TZDs), also known as Glitazones, have anti-diabetic, anti-inflammatory and anti-cancer properties. A simple, efficient and cost-effective synthesis of a thiazolidinedione compound library was developed. The synthesis is facilitated by microwave irradiation in three of the four steps followed by reduction under pressurized hydrogen gas using palladium hydroxide. All reactions, except one, were completed within an hour and provided desired products in moderate to good yields after a simple work-up.

Source: Compounds

DOI: 10.3390/compounds2030013

Authors: Fehmi Damkaci, Adam A. Szymaniak, Jason P. Biasini, Ryan Cotroneo

Institution: State University of New York at Oswego

Language: English

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,047