Work

Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis

Year: 2022

Type: article

Abstract: soaks of VcRibB-d-Ru5P crystals show accumulation in crystallo of the same intermediates. Collectively, these data reveal for the first time crucial transient chemical states in the mechanism of RibB.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.2c03376

Authors: Nikola Kenjić, Kathleen M. Meneely, Daniel J. Wherritt, Melissa C. Denler, Timothy A. Jackson, Graham R. Moran, Audrey L. Lamb

Institutions: University of Kansas, The University of Texas at San Antonio, Loyola University Chicago

Language: English

Topic: Enzyme Structure and Function

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,000

Funders: National Institutes of Health, National Institute of General Medical Sciences, Division of Chemistry, Basic Energy Sciences

Awards: G2300450775, G3715176505, G4750253330, G5199264468, G671439103, G7868574653, A Synchrotron Radiation Structural Biology Resource, G911061179

OpenAlex ID: W4284963995

FWCI: 0.561

Cites: 61

Cited by: 13

Related to: 10