Work

Impact of supervised exercise on skeletal muscle blood flow and vascular function measured with MRI in patients with peripheral artery disease

Year: 2022

Type: article

Study design: Clinical Trial

Abstract: Supervised exercise interventions can improve symptomatology in patients with peripheral artery disease, but the underlying mechanism remains unclear. Here, MRI was used to evaluate perfusion, relative tissue oxygenation, and venous oxygen saturation in response to cuff-induced ischemia. Reactive hyperemia responses were measured before and after 3 mo of randomized supervised exercise therapy or standard medical care. Those participants who were adherent to the exercise regimen had a significant improvement in peak perfusion.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00633.2021

Authors: Erin K. Englund, Michael C. Langham, Felix W. Wehrli, Molly J. Fanning, Zeeshan Khan, Kathryn H. Schmitz, Sarah J. Ratcliffe, Thomas F. Floyd, Emile R. Mohler

Institutions: University of Colorado Anschutz, University of Pennsylvania, Pennsylvania State University, University of Virginia, The University of Texas Southwestern Medical Center

Language: English

Topic: Peripheral Artery Disease Management

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Heart Association, National Institutes of Health, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences

Awards: G2574668558, G3268081124, Evaluation of skeletal muscle microvascular dysfunction in type 2 diabetes with advanced, quantitative MRI, G66900451, Colorado Clinical and Transational Sciences Institute

OpenAlex ID: W4284965874

FWCI: 1.909

Cites: 53

Cited by: 11

Related to: 10