Work

Association of Cannabis Use With Nausea and Vomiting of Pregnancy

Year: 2022

Type: article

Abstract: Our objective was to evaluate whether cannabis use was associated with nausea and vomiting in early pregnancy. Participants from nuMoM2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be) enrolled from October 2010 through September 2013 with a PUQE (Pregnancy-Unique Quantification of Emesis) questionnaire and an available stored urine sample from the first study visit (median gestational age 12 weeks) were included. Cannabis exposure was ascertained by urine immunoassay for 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH); positive results were confirmed with liquid chromatography tandem mass spectrometry. The primary outcome was moderate-to-severe nausea by the PUQE score. Overall, 9,250 participants were included, and 5.8% (95% CI 5.4-6.3%) had detectable urine THC-COOH. In adjusted analyses, higher THC-COOH levels were associated with greater odds of moderate-to-severe nausea (20.7% in the group with THC-COOH detected vs 15.5% in the group with THC-COOH not detected, adjusted odds ratio 1.6, 95% CI 1.1-2.2 for a 500 ng/mg Cr THC-COOH increment).

Source: Obstetrics and Gynecology

DOI: 10.1097/aog.0000000000004850

Authors: Torri D. Metz, Amanda A. Allshouse, Gwendolyn A. McMillin, Robert M. Silver, Marcela C. Smid, David M. Haas, Hyagriv N. Simhan, George R. Saade, William A. Grobman, Samuel Parry, Judith H. Chung, Marian P. Jarlenski

Institutions: University of Pittsburgh, University of California, Irvine, University of Utah, Indiana University Indianapolis, The Ohio State University, The University of Texas Medical Branch at Galveston, Indiana University – Purdue University Indianapolis, University of Pennsylvania

Language: English

Topic: Pregnancy and Medication Impact

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Drug Abuse, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk, G2471037088, G3094461640, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk , G3863970150, G3910300655, Utah Center for Clinical and Translational Science, G695884503, Maternal Marijuana Use and Adverse Perinatal Outcomes, Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk, Dissecting the Genetic Etiology of Preterm Birth in Nulliparous Women

OpenAlex ID: W4284967893

FWCI: 2.391

Cites: 10

Cited by: 15

Related to: 10