Role of dietary fiber in promoting immune health—An EAACI position paper
Year: 2022
Type: article
Abstract: Microbial metabolism of specific dietary components, such as fiber, contributes to the sophisticated inter-kingdom dialogue in the gut that maintains a stable environment with important beneficial physiological, metabolic, and immunological effects on the host. Historical changes in fiber intake may be contributing to the increase of allergic and hypersensitivity disorders as fiber-derived metabolites are evolutionarily hardwired into the molecular circuitry governing immune cell decision-making processes. In this review, we highlight the importance of fiber as a dietary ingredient, its effects on the microbiome, its effects on immune regulation, the importance of appropriate timing of intervention to target any potential window of opportunity, and potential mechanisms for dietary fibers in the prevention and management of allergic diseases. In addition, we review the human studies examining fiber or prebiotic interventions on asthma and respiratory outcomes, allergic rhinitis, atopic dermatitis, and overall risk of atopic disorders. While exposures, interventions, and outcomes were too heterogeneous for meta-analysis, there is significant potential for using fiber in targeted manipulations of the gut microbiome and its metabolic functions in promoting immune health.
Source: Allergy
DOI: 10.1111/all.15430
Authors: Carina Venter, Rosan W. Meyer, Matthew Greenhawt, Isabella Pali‐Schöll, Bright Nwaru, Caroline Roduit, Eva Untersmayr, Karine Adel‐Patient, Ioana Agache, Carlo Agostoni, Cezmi A. Akdis, Mary Feeney, Karin Hoffmann‐Sommergruber, Nonhlanhla Lunjani, Kate Grimshaw, Imke Reese, Peter K. Smith, Milena Sokolowska, Emilia Vassilopoulou, Berber Vlieg‐Boerstra, Shriya Amara, Jens Walter, Liam O'Mahony
Institutions: Children's Hospital Colorado, University of Colorado Anschutz, University of Colorado Denver, Imperial College London, University of Veterinary Medicine Vienna, Medical University of Vienna, University of Gothenburg, CK-CARE, University Children's Hospital Zurich, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, CEA Paris-Saclay - Etablissement de Saclay, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, CEA Paris-Saclay, Transilvania University of Brașov, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Zurich, St Thomas' Hospital, King's College London, University of Cape Town, National University of Ireland, APC Microbiome Institute, Salford Royal NHS Foundation Trust, Griffith University, International Hellenic University, OLVG, Rijnstate Hospital, University of California, Los Angeles
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,900
OpenAlex ID: W4284968105