Year: 2022
Type: article
Study design: Observational Study
Abstract: Objective. To investigate into the clinical factors associated with posttreatment recurrence and death patterns in patients with advanced esophageal cancer. Methods. Clinical information of patients with recurrence/metastasis and death after radical resection of esophageal cancer at our hospital between January 1, 2005, and December 31, 2015, were retrospectively collected and followed up. Postoperative recurrence-free survival time, postrelapse survival time, and overall survival time were compared among the metabolic-associated, organ failure-associated, and anastomotic recurrence-associated mortality groups. Results. Five hundred and ninety-five qualified patients were retrieved, including 456 males and 139 females, with an average age of 58±7.56 years. There were 57 cases of TNM-1 stage, 131 cases of TNM-2 stage, 365 cases of TNM-3 stage, and 42 cases of TNM-4 stage. There were 547 cases of squamous cell cancer and 48 cases of nonsquamous cell cancer. There were significant differences in age ( p<0.01 ), tumor location ( p<0.01 ), and lymph node metastasis ( p=0.04 ), recurrence type ( p<0.01 ) by one-way ANOVA, and recurrence-free survival ( p=0.02 ) and postrecurrence survival ( p<0.01 ) by Kaplan-Meier survival curve analysis among the three main death causes. Conclusions. Age, tumor location, and lymph node metastasis were significantly different among metabolic-associated, organ failure-associated, and anastomotic recurrence-associated mortality of recurrent EC patients.
Source: Disease Markers
DOI: 10.1155/2022/1094597
Authors: Xiangmei Zhang, Hui Wang, Dongwei He, Ming He, Xin Chen, Jidong Zhao
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,550
OpenAlex ID: W4284968606