NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease
Year: 2022
Type: preprint
Abstract: Cells respond to a myriad of stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a senescence-associated-secretory-phenotype (SASP). The heterogeneity of senescent cells (SnCs) and their SASP is vast, yet poorly characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and harmonization of their nomenclature a priority. The Cellular Senescence Network (SenNet), a NIH Common Fund initiative, will leverage emerging single cell and spatial-omics to identify and map SnCs in numerous organs across the lifespan of humans and mice. A common coordinate framework will integrate the data, using validated, standardized methods, creating public 4-dimensional SnC atlases. Key SenNet deliverables include development of innovative tools/technologies to detect SnCs, biomarker discovery, common annotations to describe SnCs and extensive public data sets. The goal is to comprehensively understand and map SnCs for diagnostic and therapeutic purposes to improve human health.
Source: Preprints.org
Authors: Patty Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer
Institutions: Duke University, Duke Medical Center, Pittsburgh Supercomputing Center, Carnegie Mellon University, Indiana University Bloomington, Indiana University, Buck Institute for Research on Aging, Washington University in St. Louis, Stanford Medicine, Stanford University, Columbia University, Northwestern University, University of Pittsburgh, Yale University, UPMC Health System, University of Pittsburgh Medical Center, Mayo Clinic, Harvard University, Duke University Hospital, National Institutes of Health, National Institute on Aging, UConn Health, University of Michigan, The Ohio State University, The University of Texas at San Antonio Health Science Center, Brown University, University of Rochester Medicine, University of Minnesota, University of Minnesota System, Jackson Laboratory, Office of the Director, Division of Program Coordination Planning and Strategic Initiatives
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4285023981