Work

Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG+-Specific B-Cells in the Rabbit Model of Experimental Syphilis

Year: 2022

Type: article

Abstract: Recent identification and structural modeling of Treponema pallidum ’s (Tp) repertoire of outer membrane proteins (OMPs) represent a critical breakthrough in the decades long quest for a syphilis vaccine. However, little is known about the antigenic nature of these β-barrel-forming OMPs and, more specifically, their surface exposed regions, the extracellular loops (ECLs).

Source: mBio

DOI: 10.1128/mbio.01639-22

Authors: Kristina N. Delgado, Jairo M. Montezuma-Rusca, Isabel C. Orbe, Melissa J. Caimano, Carson J. La Vake, Amit Luthra, Christopher M. Hennelly, Fredrick N. Nindo, Jacob W. Meyer, Letitia D. Jones, Jonathan B. Parr, Juan C. Salazar, M. Anthony Moody, Justin D. Radolf, Kelly L. Hawley

Institutions: UConn Health, University of North Carolina at Chapel Hill, Duke University, Connecticut Children's Medical Center, Duke Medical Center

Language: English

Topic: Syphilis Diagnosis and Treatment

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: Connecticut Children's Medical Center, National Institute of Allergy and Infectious Diseases

Awards: A Global Syphilis Vaccine Targeting Outer Membrane Proteins of Treponema pallidum., Characterization of Treponema pallidum rare outer membrane proteins

OpenAlex ID: W4285041387

FWCI: 3.402

Cites: 88

Cited by: 25

Related to: 10