Work

Exploring the Overlooked Roles and Mechanisms of Fibroblasts in the Foreign Body Response

Year: 2022

Type: article

Abstract: While the global implantable medical devices market is considerable and continues to appreciate in value, FBR remains one of the most common surgical implant complications. In parallel with the continued development of candidate biomaterials, further exploration of potential fibroblast subpopulations at a transcriptional level would provide key insights into further understanding the underlying mechanisms by which fibrous encapsulation occurs, and unveil novel directions for antifibrotic and regenerative therapies in the future.

Source: Advances in Wound Care

DOI: 10.1089/wound.2022.0066

Authors: Jennifer B. Parker, Michelle F. Griffin, Amanda F. Spielman, Derrick C. Wan, Michael T. Longaker

Institutions: Stanford Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: California Institute for Regenerative Medicine, National Institutes of Health, National Institute of General Medical Sciences, National Institute of Dental and Craniofacial Research