Lipoprotein subfractions and subclinical vascular health in middle aged women: does menopause status matter?
Year: 2022
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: During midlife, women experience changes in lipoprotein profiles and deterioration in vascular health measures. We analyzed the associations of groups of lipoprotein subfractions as determined by principal component analysis (PCA) with subclinical vascular health measures in midlife women and tested if these associations were modified by menopause status. METHODS: PCA was used to generate principal components (PCs) from 12 lipoprotein subfractions quantified among 545 midlife women. The associations of the identified PCs and concurrent vascular health measures were assessed using linear or logistic regressions among participants with carotid intima-media thickness (cIMT; n = 259), coronary artery calcium (n = 249), or aortic calcium (n = 248) scores. RESULTS: PCA generated four PCs representing groups of (1) small, medium, and large very low-density lipoproteins subclasses-very low-density lipoprotein PC; (2) very small, small, and medium low-density lipoprotein (LDL) subclasses-small-medium LDL-PC; (3) large and small high-density lipoproteins subclasses and midzone particles-high-density lipoprotein PC; and (4) large LDL and small intermediate-density lipoproteins-large LDL-PC. Small-medium LDL-PC was positively associated with cIMT, coronary artery calcium, and aortic calcium in unadjusted but not in adjusted models. Menopause status modified the positive association of the small-medium LDL-PC with cIMT (interaction P = 0.02) such that this association was stronger after versus before menopause ( P = 0.01). CONCLUSIONS: Carotid intimal medial thickening is positively and independently associated with small- and medium-sized LDL particles after menopause. Monitoring levels of specific lipoprotein fractions may have value in identifying midlife women at risk for developing atherosclerotic vascular disease.
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Massachusetts General Hospital, University of Pittsburgh, Rush University, Quest Diagnostics, Cerus Corporation, National Institutes of Health, University of California, Los Angeles, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Nursing Research, Office of Research on Women's Health
Awards: G1078949291, G1090129799, G1104801629, Study of Women's Health Across the Nation (SWAN) V: UCLA Site, Study of Women's Health Across the Nation (SWAN) V: Chicago site, G1650445419, G1698488551, G1796344600, Study of Women's Health Across the Nation (SWAN): New Jersey, G2114370420, G212551621, G2137320162, G2445185886, SWAN Genomic Analyses and SWAN Legacy, G2886598935, G3185656352, Study of Women's Health Across the Nation (SWAN) V: Coordinating Center, G3262555251, G3459928193, G3654623655, The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age, Study of Women's Health Across the Nation (SWAN) V: Central Laboratory, G4310344263, G4492651742, G4649022000, G5132008109, G5299499115, G5342059961, G5421556210, G5445786059, G6274672741, G6665133860, G6802717753, Study of Women's Health Across the Nation (SWAN V): Michigan Site, G7005230341, G7085063005, G7183445854, G7754319555, G7907450062, G8012083396, Study of Women's Health Across the Nation(SWAN) V: Pittsburgh, G8772865444, G8784688130, G9000166516, G9000173966, G9000284152, G9000334687, G987093159
OpenAlex ID: W4285077372