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Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary Disease

Year: 2022
Type: article
Abstract: SARS-CoV-2 or COVID-19's first case was discovered in December 2019 in Wuhan, China, and by March 2020 it was declared a pandemic by the WHO. It has been shown that various underlying conditions can increase the chance of having severe COVID-19. COPD, which is the third leading cause of death worldwide, is one of the conditions listed by the CDC which can increase the chance of severe COVID-19. The present study uses a healthy and COPD-derived bronchial airway epithelial model to study the COVID-19 and host factors which could explain the reason for COPD patients developing severe infection due to COVID-19.
DOI: 10.1128/spectrum.00459-22
Authors: Jaspreet Osan, Sattya N. Talukdar, Friederike Feldmann, Beth Ann DeMontigny, Kailey Jerome, Kristina L. Bailey, Heinz Feldmann, Masfique Mehedi
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,500
Awards: ND INBRE Health & the Environment, Dakota Cancer Collaborative on Translational Activity, G5263514522, A Multidisciplinary MARC U-STAR Program at UND, G83245612, Center for Excellence in Host Pathogen Interactions
OpenAlex ID: W4285085371
FWCI: 3.783
Cites: 101
Cited by: 31
Related to: 10