Year: 2022
Type: article
Abstract: The study of the astrocytic contribution to brain functions has been growing in popularity in the neuroscience field. In the last years, and especially since the demonstration of the involvement of astrocytes in synaptic functions, the astrocyte field has revealed multiple functions of these cells that seemed inconceivable not long ago. In parallel, cannabinoid investigation has also identified different ways by which cannabinoids are able to interact with these cells, modify their functions, alter their communication with neurons and impact behavior. In this review, we will describe the expression of different endocannabinoid system members in astrocytes. Moreover, we will relate the latest findings regarding cannabinoid modulation of some of the most relevant astroglial functions, namely calcium (Ca 2+ ) dynamics, gliotransmission, metabolism, and inflammation.
Source: Glia
DOI: 10.1002/glia.24246
Institutions: Université de Bordeaux, Inserm, Neurocentre Magendie
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,800
Awards: G181472155, G195474297, G3019809119, Decoding hypothalamic nutrient sensing and food intake regulation via mTORC1, melanocortin and endocannabinoid interactions., Cannabinoid receptors in cortical visual encoding, Bordeaux Region Aquitaine Initiative for Neuroscience, G594818701, G6086930167, Sensory representation under psychotic-like states, G7240651115, Role of mitochondrial cannabinoid type 1 receptor in hypothalamic circuits and its interaction with mTORC1 pathway during obesity.
OpenAlex ID: W4285088092