Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses
Year: 2022
Type: article
Abstract: Main Text(Stem Cell Reports 17, 1380–1394; June 14, 2022)In the Highlights section of our originally published manuscript, highlight number 3 was incorrect upon initial submission, whereas the manuscript itself was and remains otherwise entirely correct. This highlight stated, "NPC proliferative responses to bFGF correlate inversely with P-ERK levels." This bullet point was intended to highlight the inverse correlation of proliferation and P-ERK levels and has been changed to, "NPC proliferation correlates inversely with P-ERK levels." Main Text(Stem Cell Reports 17, 1380–1394; June 14, 2022)In the Highlights section of our originally published manuscript, highlight number 3 was incorrect upon initial submission, whereas the manuscript itself was and remains otherwise entirely correct. This highlight stated, "NPC proliferative responses to bFGF correlate inversely with P-ERK levels." This bullet point was intended to highlight the inverse correlation of proliferation and P-ERK levels and has been changed to, "NPC proliferation correlates inversely with P-ERK levels." (Stem Cell Reports 17, 1380–1394; June 14, 2022) In the Highlights section of our originally published manuscript, highlight number 3 was incorrect upon initial submission, whereas the manuscript itself was and remains otherwise entirely correct. This highlight stated, "NPC proliferative responses to bFGF correlate inversely with P-ERK levels." This bullet point was intended to highlight the inverse correlation of proliferation and P-ERK levels and has been changed to, "NPC proliferation correlates inversely with P-ERK levels." Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responsesConnacher et al.Stem Cell ReportsMay 26, 2022In BriefIn this article DiCicco-Bloom and colleagues show proliferation defects in neural precursor cells from idiopathic and 16p11.2-deletion forms of autism. Those exhibiting macrocephaly were hyperproliferative, while two idiopathic individuals displayed hypoproliferative phenotypes. Interestingly, 16pDel individuals also exhibited iPSC-hyperproliferative defects. These findings suggest that dysregulated proliferation may be a common phenotype in multiple forms of autism and span developmental stages. Full-Text PDF Open Access
Source: Stem Cell Reports
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,800
OpenAlex ID: W4285097011