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Editor's evaluation: SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

Year: 2021

Type: peer-review

Abstract: Deciphering the mechanism of action of a large family of natural and synthetic cytotoxic lipids bioactivated by enantiospecific oxidation into protein-reactive species inspires the development of enzyme-specific prodrugs.

DOI: 10.7554/elife.73913.sa0

Author: Benjamin F Cravatt

Institution: Scripps Research Institute

Language: English

Topic: Enzyme Catalysis and Immobilization

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W4285332211

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