Work

Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury

Year: 2022

Type: article

Abstract: The present study provides new findings that sphingosine kinase 2 (SphK2) is highly expressed in renal tubules, cisplatin treatment increases the expression of SphK2 in proximal tubular cells and kidneys, and inhibition of SphK2 alleviates cisplatin-induced kidney injury by suppressing the activation of NF-κB, production of inflammatory factors, and apoptosis. SphK2 may serve as a potential therapeutic target for the prevention or treatment of cisplatin-induced nephrotoxicity.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00229.2021

Authors: Dengpiao Xie, Gaizun Hu, Chaoling Chen, Fereshteh Ahmadinejad, Weili Wang, Pin-Lan Li, David A. Gewirtz, Ningjun Li

Institutions: Virginia Commonwealth University, Chengdu University of Traditional Chinese Medicine

Language: English

Topic: Chemotherapy-induced organ toxicity mitigation

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G1346729623, G2182594774, G2938117937, (PQ9) Mitigation of chemotherapy induced peripheral neuropathy, G3603230740, G3603235994, Molecular mechanism of hypertension-induced renal injury: the role of HIF-1alpha, G4245463641, G454850423, G4705032239, Hypertension and glomerular injury in hyperhomocysteinemia - role of inflammatory exosomes, Lysosome dysfunction in podocytopathy and associated hypertension, G7525927418, G7680286318, G8270635188

OpenAlex ID: W4285387933

FWCI: 1.126

Cites: 81

Cited by: 10

Related to: 10