Complex physiology and clinical implications of time-restricted eating
Year: 2022
Type: review
Abstract: Time-restricted eating (TRE) is a dietary intervention that limits food consumption to a specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have shown considerable therapeutic effects of TRE and important interactions among time of eating, circadian biology, and metabolic homeostasis. In contrast, it is difficult to make firm conclusions regarding the effect of TRE in people because of the heterogeneity in results, TRE regimens, and study populations. In this review, we 1) provide a background of the history of meal consumption in people and the normal physiology of eating and fasting; 2) discuss the interaction between circadian molecular metabolism and TRE; 3) integrate the results of preclinical and clinical studies that evaluated the effects of TRE on body weight and physiological functions; 4) summarize other time-related dietary interventions that have been studied in people; and 4) identify current gaps in knowledge and provide a framework for future research directions.
Source: Physiological Reviews
Language: English
Topic: Dietary Effects on Health
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Veterans Affairs, American Heart Association, Paul and Daisy Soros Fellowships for New Americans, Foundation for Barnes-Jewish Hospital, Endocrine Fellows Foundation, National Institutes of Health, National Institute of Food and Agriculture, National Institute on Alcohol Abuse and Alcoholism, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences
Awards: G1072803671, G1093464239, G1143187280, G1239756754, G151374072, G156123175, G1625418467, G1912511563, G2118513338, G2178854900, G222473375, G2337220457, G2736159683, G2824222223, G2928778974, G297113894, G3064501752, G3587449177, G444632500, G4653923755, G5357063758, G6551102136, G680976502, G8094896026, Diabetes Research Center, UC San Diego Clinical and Translational Research Institute, The effect of time-restricted eating in cardiometabolic health, UC Davis Clinical and Translational Science Center, Washington University Nutrition Obesity Research Center, San Diego Digestive Diseases Research Center, Cancer Center Support Grant (CCSG), Diabetes Research Center (DRC), Southern California Research Center for ALPD and Cirrhosis, Host-environment interactions in the pathophysiology of digestive disease
OpenAlex ID: W4285388525