Work

Studies of ultrastructure, gene expression, and marker analysis reveal that mouse bladder PDGFRA+ interstitial cells are fibroblasts

Year: 2022

Type: article

Abstract: We currently lack basic insights into the fibroblasts that populate the bladder wall. By exploring the ultrastructure of mouse bladder connective tissue cells, combined with analyses of their gene and protein expression, our study revealed that PDGRA+ interstitial cells (also referred to as myofibroblasts, telocytes, and interstitial cells of Cajal-like cells) are fibroblasts and that the bladder wall contains multiple, regionally distinct populations of these cells.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00135.2022

Authors: Dennis R. Clayton, Wily G. Ruiz, Marianela G. Dalghi, Nicolas Montalbetti, Marcelo D. Carattino, Gerard Apodaca

Institution: University of Pittsburgh

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Urological Association Foundation, National Institutes of Health, NIH Office of the Director, National Institute of Diabetes and Digestive and Kidney Diseases