Year: 2022
Type: review
Abstract: Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans from organelles to populations, and new technologies can accommodate investigation across these scales. Here, we review recent advancements in metabolic analysis, including small-scale metabolomics techniques amenable to organelles and rare cell types, functional screening to explore how cells respond to metabolic stress, and imaging approaches to non-invasively assess metabolic perturbations in diseases. We discuss how metabolomics provides an informative phenotypic dimension that complements genomic analysis in Mendelian and non-Mendelian disorders. We also outline pressing challenges and how addressing them may further clarify the biochemical basis of human disease.
Source: Cell
Authors: Ralph J. DeBerardinis, Kayvan R. Keshari
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $9,900
Awards: G2198109825, Metabolic Enablers of Melanoma Progression, G3034106355, Visualizing oxidative stress using hyperpolarized magnetic resonance, G4654774211, Targeting Lung Cancer Vulnerabilities, G6372001402, G6547342617, G697995447, G7110844123, Development of large-field-of-view hyperpolarized MRI, G8083789117, Cancer Center Support Grant, Human metabolic variation as a window into cancer initiation and progression, UT Southwestern NORC, University of Texas Southwestern Medical Center SPORE in Kidney Cancer, Leveraging fructose transport to create a privileged substrate to selectively fuel T cells, Image-guided Trp-IDO/TDO-Kyn-AHR pathway inhibition, combined with immunotherapy
OpenAlex ID: W4285404902