Work

Recent Advances with KDM4 Inhibitors and Potential Applications

Year: 2022

Type: review

Abstract: The histone lysine demethylase 4 (KDM4) family plays an important role in regulating gene transcription, DNA repair, and metabolism. The dysregulation of KDM4 functions is associated with many human disorders, including cancer, obesity, and cardiovascular diseases. Selective and potent KDM4 inhibitors may help not only to understand the role of KDM4 in these disorders but also to provide potential therapeutic opportunities. Here, we provide an overview of the field and discuss current status, challenges, and opportunities lying ahead in the development of KDM4-based anticancer therapeutics.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.2c00680

Authors: Qiong Wu, Brandon Young, Yan Wang, Andrew M. Davidoff, Zoran Rankovic, Jun Yang

Institutions: St. Jude Children's Research Hospital, University of Tennessee Health Science Center

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, National Institutes of Health, National Cancer Institute