Metronidazole-loaded nanoparticulate thermoreversible gel for gynecologic infection of Trichomonas vaginalis.
Year: 2022
Type: article
Abstract: OBJECTIVE: ). METHODS: efficacy in the BALB/c mouse model. RESULT: A nearly threefold rise in antiparasitic activity of the optimized formulation was observed as compared to that of regular gel. Formulation F5 successfully cured the trichomoniasis within 3 days, while regular gel and pure Metronidazole (MTDZ) failed to cure this infection (P<0.05). CONCLUSION: . The developed gel could be an alternative to the existing drug delivery system for the treatment of trichomoniasis.
Source: PubMed
Authors: Ling Fang, Xianyi Lu, Chengjun Cui, Qifeng Shi, Haojue Wang
Institution: Zhongda Hospital Southeast University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4285611164