The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway
Year: 2022
Type: article
Abstract: The ability of an arthropod to harbor and transmit pathogens is termed "vector competency." Many factors influence vector competency, including how arthropod immune processes respond to the microbe. Divergences in innate immunity between arthropods are increasingly being reported. For instance, although ticks lack genes encoding key upstream molecules of the immune deficiency (IMD) pathway, it is still functional and restricts causative agents of Lyme disease (Borrelia burgdorferi) and anaplasmosis (Anaplasma phagocytophilum). How the IMD pathway is activated in ticks without classically defined pathway initiators is not known. Here, we found that a cellular stress response network, the unfolded-protein response (UPR), functions upstream to induce the IMD pathway and restrict transmissible pathogens. Collectively, this explains how the IMD pathway can be activated in the absence of canonical pathway initiators. Given that the UPR is highly conserved, UPR-initiated immunity may be a fundamental principle impacting vector competency across arthropods.
Source: mBio
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,900
Awards: Exploiting a cyclic dinucleotide-mediated immune response to reduce the burden of Coxiella burnetii infection, Defining the mechanistic determinants of catalytic bias in cofactor-based enzymatic oxidation-reduction reactions, Training in Biotechnology: Emphasis in Protein Chemistry, TICK-PATHOGEN INTERFACE: INVESTIGATING CROSSTALK BETWEEN STRESS RESPONSES AND IMMUNITY
OpenAlex ID: W4285727780