Year: 2022
Type: article
Study design: Observational Study
Abstract: Genetic influence on lung functions has been identified in previous studies; however, the relative longitudinal effects of genetic factors and their interactions with smoking on lung function remain unclear. Here, we identified the longitudinal effects of genetic variants on lung function by determining single nucleotide polymorphism (SNP) heritability and genetic correlations, and by analyzing interactions with smoking. Subject-specific means and annual change rates were calculated for eight spirometric measures obtained from 6622 Korean adults aged 40−69 years every two years for 14 years, and their heritabilities were estimated separately. Statistically significant (p < 0.05) heritability for the subject-specific means of all spirometric measures (8~32%) and change rates of forced expiratory volume in 1 s to forced vital capacity ratio (FEV1/FVC; 16%) and post-bronchodilator FEV1/FVC (17%) were detected. Significant genetic correlations of the change rate with the subject-specific mean were observed for FEV1/FVC (ρg = 0.64) and post-bronchodilator FEV1/FVC (ρg = 0.47). Furthermore, post-bronchodilator FEV1/FVC showed significant heritability of SNP-by-smoking interaction (hGXS2 = 0.4) for the annual change rate. The GWAS also detected genome-wide significant SNPs for FEV1 (rs4793538), FEV1/FVC (rs2704589, rs62201158, and rs9391733), and post-bronchodilator FEV1/FVC (rs2445936). We found statistically significant evidence of heritability role on the change in lung function, and this was shared with the effects on cross-sectional measurements. We also found some evidence of interaction with smoking for the change of lung function.
Source: Genes
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,513
Funders: Korea Medical Institute, Korea Disease Control and Prevention Agency, National Research Foundation, Korea University, Ministry of Science, ICT and Future Planning, Ministry of Science and ICT, South Korea, Centers for Disease Control and Prevention, Korea Centers for Disease Control and Prevention
Awards: G1021138356, G102164538, G1024797658, G1069213372, G1103243589, G1118934911, G1146594612, G1257197375, G1328289814, G1413055516, G1437315919, G1484546377, G1550274400, G1564362858, G1613048862, G1626098974, G168224276, G1698593809, G1812920287, G1817185175, G190979531, G2033424395, G2057062532, G2070982718, G2075269403, G2075718497, G2086554191, G2298158694, G2350796569, G2366292454, G2374307435, G2408106943, G2444264054, G2464961314, G2494992890, G2553818335, G2637412598, G2638149451, G2656520920, G269605904, G2734521887, G2786402816, G2834711070, G2947798276, G2984935349, G3008616891, G3030330391, G3104701010, G3141223461, G3158276977, G317166507, G3193728039, G3210667196, G3252968034, G3269040175, G3319219700, G3405844368, G3436941876, G3471358265, G3519222841, G3567202758, G3585806100, G3633588294, G3638923273, G3772561140, G3810314906, G3816517900, G3858889831, G391674171, G3933212243, G3946734855, G407142740, G4146437826, G4276639378, G4371125774, G4458831664, G4526150034, G4583891812, G4594536228, G4607598791, G464832803, G4759921151, G4780114640, G4857119214, G492231104, G5046635779, G5050681847, G5144894083, G5226369942, G5237557701, G524119356, G5246897706, G5277991875, G5366762715, G551221310, G5552003537, G5584893550, G5708591079, G5764166624, G5771348167, G5827367843, G5848509105, G5870570524, G5913338663, G5933603345, G605105935, G6082747193, G6108387770, G6264869458, G6348878851, G6404156740, G6428138145, G6549285687, G6599860329, G6609346327, G6621016479, G6751539817, G6764920933, G6781386558, G682336887, G6869433168, G688329965, G6926456125, G7083467730, G709347329, G710311190, G7105704331, G7106696801, G7152094987, G729057583, G7371837632, G7387505168, G7463462991, G7494855773, G753142989, G7562468729, G7631516172, G7756463622, G7761831544, G7863083613, G7878130237, G7955800939, G7960541367, G8085464812, G808739799, G8118825682, G8140715260, G8189630030, G8256999862, G8282130130, G8617669464, G8625801736, G8635073081, G8665005248, G8686218975, G8748540566, G8790588530, G8805097397, G8862067976, G8864520149, G919079370, G922085245, G927910669, G953516847
OpenAlex ID: W4285733230