Work

Evidence of histone modification affecting ARID1A expression in colorectal cancer cell lines.

Year: 2022

Type: article

Abstract: Aim: expression in colorectal cancer cell lines. Background: suppression in colorectal cancer remains unclear. Methods: The expression levels of ARID1A mRNA were determined using real-time quantitative PCR in colorectal cancer cell lines including HCT116, SW48, HT29, SW742, LS180, and SW480. To evaluate the effect of histone deacetylation on ARID1A expression, all cell lines were treated with trichostatin A (TSA), a histone deacetylase inhibitor. SPSS software (Version 23) and GraphPad Prism (Version 6.01) were applied for data analysis using one-way ANOVA, followed by Tukey's multiple comparison tests. Results: downregulation in colorectal cancer. Conclusion: expression and may bring benefits to the colorectal cancer patients with a broader range of genetic backgrounds.

Source: Gastroenterology and hepatology from bed to bench.

Authors: Mehran Erfani, Mozhdeh Zamani, Pooneh Mokarram

Institutions: Shiraz University of Medical Sciences, Hormozgan University of Medical Sciences

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Shiraz University of Medical Sciences

OpenAlex ID: W4285739692

FWCI: 0.375

Cites: 35

Cited by: 6

Related to: 10