Work

The role of MiT/TFE family members in autophagy regulation.

Year: 2021

Type: article

Abstract: The MiT/TFE family of proteins are important regulators of a number of metabolic processes. One of their most important roles is activating the autophagy pathway in the setting of nutrient deprivation or buildup of toxic metabolites. Their proper and improper functioning in this role has been linked to several types of disease, including cancer and multiple forms of neurodegeneration. In this review we will briefly outline what is known about individual family members' roles in regulating autophagy across a variety of contexts.

Source: PubMed

Authors: Nicholas Theodosakis, Angel D Pagan, David E Fisher

Institutions: Massachusetts General Hospital, Ponce Health Sciences University

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: A druggable dependency in low-MITF/high-AXL melanoma: preclinical efficacy and mechanism of action in a key treatment-resistant subclass., Therapeutic strategies for treatment of giant congenital melanocytic nevi, MITF from control of pigmentation to melanoma risk, Targetable epigenetic and transcriptional mechanisms in melanoma thatshape the microenvironment