Association of Physical Activity With Bioactive Lipids and Cardiovascular Events
Year: 2022
Type: article
Abstract: BACKGROUND: To clarify the mechanisms underlying physical activity (PA)-related cardioprotection, we examined the association of PA with plasma bioactive lipids (BALs) and cardiovascular disease (CVD) events. We additionally performed genome-wide associations. METHODS: PA-bioactive lipid associations were examined in VITAL (VITamin D and OmegA-3 TriaL)-clinical translational science center (REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT01169259; N=1032) and validated in JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin)-NC (REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT00239681; N=589), using linear models adjusted for age, sex, race, low-density lipoprotein-cholesterol, total-C, and smoking. Significant BALs were carried over to examine associations with incident CVD in 2 nested CVD case-control studies: VITAL-CVD (741 case-control pairs) and JUPITER-CVD (415 case-control pairs; validation). RESULTS: We detected 145 PA-bioactive lipid validated associations (false discovery rate <0.1). Annotations were found for 6 of these BALs: 12,13-diHOME, 9,10-diHOME, lysoPC(15:0), oxymorphone-3b-D-glucuronide, cortisone, and oleoyl-glycerol. Genetic analysis within JUPITER-NC showed associations of 32 PA-related BALs with 22 single-nucleotide polymorphisms. From PA-related BALs, 12 are associated with CVD. CONCLUSIONS: We identified a PA-related bioactive lipidome profile out of which 12 BALs also had opposite associations with incident CVD events.
Source: Circulation Research
Authors: Rosangela A. Hoshi, Yanyan Liu, Heike Luttmann-Gibson, Saumya Tiwari, Franco Giulianini, Allen M. Andres, Jeramie D. Watrous, Nancy R. Cook, Karen H. Costenbader, Olivia I. Okereke, Paul M Ridker, JoAnn E. Manson, I-Min Lee, Manickavasagar Vinayagamoorthy, Susan Cheng, Trisha Copeland, Mohit Jain, Daniel I. Chasman, Olga V. Demler, Samia Mora
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
Funders: National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Center for Complementary and Integrative Health
Awards: VITAL-DEP Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL, Mediators of Systemic Inflammation and Heart Failure Risk in the Community, Reducing Inflammation for the Prevention of CVD: A Focus on Eicosanoid Pathways, Inflammatory Mediators, Cardiovascular Health, and Longevity in Women, VITamin D and omegA-3 triaL (VITAL), Consensus Framework for Cardiovascular Risk Prediction in a Clinical Setting, Vitamin D and Fish Oil for Autoimmune Disease and Inflammation, Women's Health Study: Infrastructure support for cohort follow-up, The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE), VITAL-DEP (VITamin D and OmegA 3 TriaL-Depression Endpoint Prevention), The VITamin D and OmegA-3 TriaL (VITAL), CHD Risk and Metabolomic Profiles of Discordant Lipids, Mentored Patient-Oriented Research for Preventing ASCVD Events, The VITamin D and OmegA-3 TriaL (VITAL): Post-Intervention Follow-Up, Circulating plasma metabolites, diet, and risk of type 2 diabetes
OpenAlex ID: W4285796198