Work

Myeloid-derived suppressor cells in cancer

Year: 2022

Type: review

Abstract: Numerous recent studies have shown that myeloid-derived suppressor cells (MDSCs), a strongly heterogeneous population of immunosuppressive cells, are dysregulated in the presence of many cancers. MDSCs present different phenotypes and play prominent roles in the tumor microenvironment. To date, gene therapies targeting MDSCs are the most innovative and flexible methods to specifically modify the tumor microenvironment. Here, we summarize current studies related to the phenotypes, functions, and mechanisms of MDSCs and explore the therapeutic landscape of chemokines that affect the balance between subpopulations of MDSCs.

Source: iLiver

DOI: 10.1016/j.iliver.2022.06.002

Authors: Jun Gao, Wei-Ren Liu, Zheng Tang, Jia Fan, Ying-Hong Shi

Institutions: Fudan University, Zhongshan Hospital, State Key Laboratory of Genetic Engineering

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,600