Application of metagenomic next-generation sequencing in the diagnosis of infectious diseases of the central nervous system after empirical treatment
Year: 2022
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The diagnostic value of metagenomic next-generation sequencing (mNGS) in central nervous system (CNS) infectious diseases after empirical treatment has not been reported. AIM: To investigate the diagnostic value of mNGS of cerebrospinal fluid (CSF) in the empirically treated CNS infectious diseases. METHODS: A total of 262 CSF samples from patients with suspected CNS infections were collected between August 2020 and December 2021. Both mNGS and conventional methods were used for testing. The conventional methods included microbial culture, smear, polymerase chain reaction, RESULTS: < 0.001). The results showed that compared with conventional methods, mNGS technology was a more sensitive method for the diagnosis of CNS infection after empirical treatment. CONCLUSION: mNGS can be a better method applied in the diagnosis of CNS infection after empirical treatment.
Source: World Journal of Clinical Cases
Authors: Ying-Ying Chen, Yan Guo, Xin-Hong Xue, Feng Pang
Institution: Liaocheng People's Hospital
Language: English
Subfield: Clinical Biochemistry
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4286432861