Work

Extracellular Matrix Microparticles Improve GelMA Bioink Resolution for 3D Bioprinting at Ambient Temperature

Year: 2022

Type: article

Abstract: Introduction: Current bioinks for 3D bioprinting, such as gelatin-methacryloyl, are generally low viscosity fluids at room temperature, requiring specialized systems to create complex geometries. Methods and Results: Adding decellularized extracellular matrix microparticles derived from porcine tracheal cartilage to gelatin-methacryloyl creates a yield stress fluid capable of forming self-supporting structures. This bioink blend performs similarly at 25°C to gelatin-methacryloyl alone at 15°C in linear resolution, print fidelity, and tensile mechanics. Conclusion: This method lowers barriers to manufacturing complex tissue geometries and removes the need for cooling systems.

Source: Macromolecular Materials and Engineering

DOI: 10.1002/mame.202200196

Authors: Zachary Galliger, Caleb D. Vogt, Haylie R. Helms, Angela Panoskaltsis‐Mortari

Institution: University of Minnesota

Language: English

Topic: 3D Printing in Biomedical Research

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $3,900

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences