Work

The Role of PIM Kinases in Pediatric Solid Tumors

Year: 2022

Type: review

Abstract: PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials.

Source: Cancers

DOI: 10.3390/cancers14153565

Authors: Janet Rae Julson, Raoud Marayati, Elizabeth Ann Beierle, Laura Lee Stafman

Institutions: University of Alabama at Birmingham, Vanderbilt University

Language: English

Topic: Cancer Mechanisms and Therapy

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,513