Work

Okazaki fragment maturation: DNA flap dynamics for cell proliferation and survival

Year: 2022

Type: review

Abstract: Unsuccessful processing of Okazaki fragments leads to the accumulation of DNA breaks which are associated with many human diseases including cancer and neurodegenerative disorders. Recently, Okazaki fragment maturation (OFM) has received renewed attention regarding how unprocessed Okazaki fragments are sensed and repaired, and how inappropriate OFM impacts on genome stability and cell viability, especially in cancer cells. We provide an overview of the highly efficient and faithful canonical OFM pathways and their regulation of genomic integrity and cell survival. We also discuss how cells induce alternative error-prone OFM processes to promote cell survival in response to environmental stresses. Such stress-induced OFM processes may be important mechanisms driving mutagenesis, cellular evolution, and resistance to radio/chemotherapy and targeted therapeutics in human cancers.

Source: Trends in Cell Biology

DOI: 10.1016/j.tcb.2022.06.014

Authors: Haitao Sun, Lingzi Ma, Ya-Fang Tsai, Tharindu Abeywardana, Binghui Shen, Li Zheng

Institutions: City Of Hope National Medical Center, City of Hope, Beckman Research Institute

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $6,700