Year: 2021
Type: article
Abstract: The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natural and laboratory Brugia populations, there is a lack of sequence diversity on chromosome X relative to the autosomes (πX/πA = 0.2), which is lower than the expected (πX/πA = 0.75). A reduction in diversity is also observed in other filarial nematodes with neo-X chromosome fusions in the genera Onchocerca and Wuchereria, but not those without neo-X chromosome fusions in the genera Loa and Dirofilaria. In the species with neo-X chromosome fusions, chromosome X is abnormally large, containing a third of the genetic material such that a sizable portion of the genome is lacking sequence diversity. Such profound differences in genetic diversity can be consequential, having been associated with drug resistance and adaptability, with the potential to affect filarial eradication.
Source: PLoS neglected tropical diseases
Authors: John Mattick, Silvia Libro, Robin Bromley, Wanpen Chaicumpa, Matthew Chung, Darren Cook, Mohammad Behram Khan, Nikhil Kumar, Yee-Ling Lau, Shailja Misra-Bhattacharya, Ramakrishna Rao, Lisa Sadzewicz, Atiporn Saeung, Mohd Shahab, Benjamin C. Sparklin, Andrew Steven, Joseph D. Turner, Luke J. Tallon, Mark J. Taylor, Andrew R. Moorhead, Michelle Michalski, Jeremy M. Foster, Julie C. Dunning Hotopp
Institutions: University of Maryland, Baltimore, New England Biolabs (United States), Siriraj Hospital, Mahidol University, Liverpool School of Tropical Medicine, University of Malaya, Central Drug Research Institute, Washington University in St. Louis, Chiang Mai University, University of Georgia, University of Wisconsin–Oshkosh
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,420
OpenAlex ID: W3210457138