Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice
Year: 2021
Type: article
Abstract: Supplemental Table 1. Five mice lacking intestinal SMAD4 expression ("KO") and five littermate control mice ("WT") had their colon microbiome composition compared. 16S targeted sequencing was performed on mouse stool pellets ("Pellet") and colon mucosal scrapings ("Scraping") and compared at the phylum, class, order, family, genus, and species levels. Values represent proportion of organisms detected per sample. Genotypes were split evenly between sexes. The five female mice were co-housed and the five male mice were co-housed, with bedding mixed between cages weekly.
Authors: Marincola Smith, Paula, Choksi, Yash A., Markham, Nicholas O., Hanna, David N., Zi, Jinghuan, Weaver, Connie J., Hamaamen, Jalal A., Lewis, Keeli B., Yang, Jing, Liu, Qi, Kaji, Izumi, Means, Anna L., Beauchamp, R. Daniel
Institution: Vanderbilt University Medical Center
Language: English
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W6912482518