Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality
Year: 2021
Type: article
Study design: Observational Study
Abstract: The relationship between dietary factors and liver disease remains poorly understood. This study evaluated the associations of whole grain and dietary fiber intake with liver cancer risk and chronic liver disease mortality. The National Institutes of Health–American Association of Retired Persons Diet and Health Study cohort recruited 485, 717 retired U.S. participants in 1995–1996. Follow-up through 2011 identified 940 incident liver cancer cases and 993 deaths from chronic liver disease. Compared with the lowest, the highest quintile of whole grain intake was associated with lower liver cancer risk (Hazard ratio [HR]Q5 vs. Q1 = 0.78, 95% confidence interval [CI]: 0.63–0.96) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.44, 95% CI: 0.35–0.55) in multivariable Cox models. Dietary fiber was also associated with lower liver cancer risk (HRQ5 vs. Q1 = 0.69, 95% CI: 0.53–0.90) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.37, 95% CI: 0.29–0.48). Fiber from vegetables, beans and grains showed potential protective effect. Here, we show that higher intake of whole grain and dietary fiber are associated with lower risk of liver cancer and liver disease mortality.
Source: Nature Communications
Institutions: Harvard University, Fudan University, Brigham and Women's Hospital, Anhui Medical University, Boston University, National Cancer Institute, Division of Cancer Epidemiology and Genetics, American Cancer Society, University of California, Los Angeles, UCLA Jonsson Comprehensive Cancer Center
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,560
Funders: U.S. Department of Health and Human Services, American Cancer Society, U.S. Department of State, Pennsylvania Department of Health, Florida Department of Health, Emory University, Arizona Department of Health Services, Dana-Farber/Harvard Cancer Center, Louisiana State University, Harvard T.H. Chan School of Public Health, Missouri Department of Health and Senior Services, Texas Department of State Health Services, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute
OpenAlex ID: W3209812026