Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
Year: 2021
Type: article
Abstract: A broad defense against SARS-like viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third coronavirus that has emerged as a serious human pathogen in the past 20 years. Treatment strategies that are broadly protective against current and future SARS-like coronaviruses are needed. Martinez et al . take on this challenge by developing vaccines based on chimeras of the viral spike protein. The messenger RNA vaccines encode spike proteins composed of domain modules from epidemic and pandemic coronaviruses, as well as bat coronaviruses with the potential to cross to humans. In aged mice vulnerable to infection, the chimeric vaccines protected against challenge from SARS-CoV, SARS-CoV-2 and tested variants of concern, and zoonotic coronaviruses with pandemic potential. —VV
Source: Science
Authors: David R. Martinez, Alexandra Schäfer, Sarah R. Leist, Gabriela De la Cruz, Ande West, Elena N. Atochina-Vasserman, Lisa C. Lindesmith, Norbert Pardi, Robert Parks, Maggie Barr, Dapeng Li, Boyd Yount, Kevin O. Saunders, Drew Weissman, Barton F. Haynes, Stephanie A. Montgomery, Ralph S. Baric
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: Human antibody-based countermeasures against the Wuhan Coronavirus SARS-CoV-2, Determinants of Coronavirus Fidelity in Replication and Pathogenesis, Broad-spectrum antiviral GS-5734 to treat MERS-CoV and related emerging CoV, G1679713219, G2298674817, G2678568294, Defining viral and immune mechanisms of Dengue virus serotype 2 immune evasion, G3055706296, Respiratory Virus Vaccine and Adjuvant Exploration, North Carolina Seronet Center for Excellence, G4560865878, Systems Immunogenetics of Biodefense and Emerging Pathogens in the Collaborative Cross, G5247632879, G5854035082, G59380150, Nucleoside modified mRNA based HIV vaccine, G6054129285, G6648906605, Antiviral Drug Discovery and Development Center (AD3C), G7258925289, Cell entry, cross-species transmission and pathogenesis of novel coronavirus from, Cancer Center Support Grant, G918283569, Infectious Disease Pathogenesis Research Training Program
OpenAlex ID: W3175969873