Work

From development to cancer - an ever-increasing role of AGR2.

Year: 2021

Type: review

Abstract: , where it plays an important function in embryonic development. Akin to several other developmental genes, it is also frequently deregulated in cancer, where it plays a decisive role in tumor initiation, progression and metastasis. In this review, we have summarized currently known AGR2 functions, its expression and function in embryonic and cancer development, as well as its potential as a candidate tumor biomarker and promising new target for cancer immunotherapy.

Source: PubMed

Authors: Daria Jach, Yuzhu Cheng, Filip Prica, Laurent Dumartin, Tatjana Crnogorac-Jurcevic

Institutions: Queen Mary University of London, Barts Cancer Institute, Centre for Life, Newcastle University, Novartis (France)

Language: English

Topic: Cancer Mechanisms and Therapy

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4287461718

FWCI: 0.465

Cites: 112

Cited by: 27

Related to: 10