The risk of subclinical carotid atherosclerosis in patients with chronic hepatitis C.
Year: 2021
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: The role of hepatitis C virus in the pathogenesis of atherosclerotic disease has been suggested by several studies. AIM: To assess the association between subclinical carotid atherosclerosis and chronic hepatitis C. METHODS: 40 patients infected with chronic hepatitis C and 40 control cases were evaluated by anthropometric and metabolic measurements. The risk of subclinical atherosclerosis was assessed by ultrasound measurement of carotid intima-media thickness. A high cardiovascular risk atherosclerosis was defined by carotid intima-media thickness > 75th percentile. RESULTS: The carotid intima-media thickness and the prevalence of high cardiovascular risk atherosclerosis were significantly higher in the group infected with hepatitis C compared to the control group (0.68 VS 0.60, p=0.02) and (82.5% vs. 40%; 0.001) respectively. In multivariate studies, activity ≥ A2 and age> 40 years were the independent factors associated with the carotid intima-media thickness and hepatitis C was the only independent factor associated with high cardiovascular risk atherosclerosis (OR=4.81 CI at 95%: 1.6-14.42). CONCLUSIONS: In our study, chronic hepatitis C was associated with a high risk of carotid atherosclerosis.
Source: PubMed
Language: English
Topic: Hepatitis C virus research
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4287544343