Work

A structural model for the Coronavirus Nucleocapsid

Year: 2020

Type: preprint

Abstract: We propose a mesoscale model structure for the coronavirus nucleocapsid, assembled from the high resolution structures of the basic building blocks of the N-protein, CryoEM imaging and mathematical constraints for an overall quasi-spherical particle. The structure is a truncated octahedron that accommodates two layers: an outer shell composed of triangular and quadrangular lattices of the N-terminal domain and an inner shell of equivalent lattices of coiled parallel helices of the C-terminal domain. The model is consistent with the dimensions expected for packaging large viral genomes and provides a rationale to interpret the apparent pleomorphic nature of coronaviruses.

Source: arXiv (Cornell University)

DOI: 10.48550/arxiv.2005.12165

Authors: Coscio, Federico, Nadra, Alejandro D., Ferreiro, Diego U.

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Universidad Católica de Salta

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Aeronautics and Space Administration, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, NASA Astrobiology Institute, Agencia Nacional de Promoción Científica y Tecnológica

OpenAlex ID: W4287775650

Cites:

Cited by: 4

Related to: 10