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Cabotegravir Is Not Associated With Weight Gain in Human Immunodeficiency Virus–uninfected Individuals in HPTN 077

Year: 2019

Type: article

Abstract: Studies in human immunodeficiency virus (HIV)-infected individuals suggest excess weight gain with integrase inhibitor-based antiretroviral therapy. The HIV Prevention Trials Network Study 077 evaluated changes in weight and fasting metabolic parameters in HIV-uninfected individuals randomized to cabotegravir or a placebo. No differences between arms were found for change in weight or fasting metabolic parameters overall or for subgroups.

Source: Clinical Infectious Diseases

DOI: 10.1093/cid/ciz439

Authors: Raphael J Landovitz, Sahar Z Zangeneh, Gordon Chau, Beatriz Grinsztejn, Joseph J Eron, Halima Dawood, Manya Magnus, Albert Y Liu, Ravindre Panchia, Mina C Hosseinipour, Ryan Kofron, David A Margolis, Alex Rinehart, Adeola Adeyeye, David Burns, Marybeth McCauley, Myron S Cohen, Judith S Currier

Institutions: University of California, Los Angeles, Fred Hutch Cancer Center, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, University of North Carolina at Chapel Hill, University of KwaZulu-Natal, George Washington University, San Francisco Department of Public Health, University of the Witwatersrand, Perinatal HIV Research Unit, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Family Health International 360

Language: English

Topic: HIV-related health complications and treatments

Subfield: Emergency Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: ViiV Healthcare, Fundação Oswaldo Cruz, National Institutes of Health, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases

Awards: G2548217053, Developing appropriate risk reduction interventions for pre-teens, UCLA AIDS Prevention and Treatment Clinical Trials Unit, G793395730, G9000027606, G9000035439, G9000072712, The FIOCRUZ Therapeutic and Prevention HIV/AIDS Clinical Trials Unit., University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit, UCLA AIDS Prevention and Treatment Clinical Trials Unit, KwaZulu-Natal Clinical Trials Unit, PHRU-Setshaba Clinical Trials Unit, G95499620, G95938990

OpenAlex ID: W2945214389

FWCI: 7.55

Cites: 13

Cited by: 45

Related to: 10