Role of Executive Function in Response to a Problem Solving Based Psychoeducational Intervention in Adolescents with Psychosis: The PIENSA Trial Revisited
Year: 2019
Type: article
Abstract: An improvement in negative symptoms and a reduction in the number of visits to the emergency department have been reported in a problem solving based psychoeducational group intervention (PE) for adolescents with psychosis relative to a nonstructured group (NS). One of the factors that may play a role on the response to PE treatment is executive function (EF), a crucial cognitive domain for problem-solving performance. We aimed to examine the role of EF in response to PE treatment versus an NS group. We examined the associations between changes in cognition and in clinical/functional variables within each treatment group using Spearman-ranked and partial correlation analyses. A total of 22 individuals (mean age: 16.3) were randomized to PE (N = 10) and NS (N = 12). We found an association between improvements in EF performance and a reduction in positive symptoms (rs = –0.756, p = 0.030 for semantic fluency), reduction in negative symptoms (r = 0.758, p = 0.029 for semantic; rs = –0,733, p = 0.025 for verbal fluency), and reduction in the number of visits to the emergency department (r = –0,743, p = 0.035 for semantic fluency) in the PE group. No associations were found in the NS group. Our results suggest that EF may play a role in the specific improvements observed in the PE group. This may have implications in the development of new areas of clinical intervention focusing on the role of cognitive functioning in response to psychosocial treatments in psychosis.
Source: Journal of Clinical Medicine
DOI: 10.3390/jcm8122108
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,824
Funders: Fundación Mutua Madrileña, Fundación Alicia Koplowitz, National Alliance for Research on Schizophrenia and Depression, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades, European Commission, Ministerio de Economía y Competitividad, Centro de Investigación Biomédica en Red de Salud Mental, Horizon 2020 Framework Programme, Instituto de Salud Carlos III, European Regional Development Fund, FP7 Health
Awards: G1033681661, G1297764492, G1520406698, G1613104404, G1886919625, G1897392993, G1998051719, G2017605187, G2166927188, G2972662694, G3210393749, G3764841371, G3920792168, G4435369794, Translating neuroimaging findings from research into clinical practice, G4827590587, G5031224452, G5983053349, G6081615879, OPtimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE), G6446975009, Autism Innovative Medicine Studies – 2 – Trials, G6844935297, G7114038015, G7336256237, Estudio longitudinal de marcadores oxidativos y neuroinflamatorios de la función cognitiva en primeros episodios de psicosis adolescente, Neuroimaging platform for characterisation of metabolic co-morbidities in psychotic disorders, Estudio multicentrico del maltrato en la infancia y el riesgo para enfermedad mental en niños y adolescentes: análisis de modificaciones epigenéticas y de su correlato con biomarcadores de inmunidad innata en un modelo periférico, G7811397228, G7902974348, European Network of National Schizophrenia Networks Studying Gene-Environment Interactions, Psychiatric Ratings using Intermediate Stratified Markers - Sofia ref.: 115916, G8351277590, G85705433, G8950770007
OpenAlex ID: W2990924737