Work

Oleic amide derivatives as small molecule stimulators of the human proteasome's core particle

Year: 2022

Type: article

Abstract: A series of oleic acid amide derivatives were generated as potential small molecule stimulators of the 20S core particle of the proteasome (20S CP), with the goal of increasing the protein degradation rate via the ubiquitin-independent pathway.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d2md00133k

Authors: Saayak Halder, Nathaniel J. Macatangay, Breanna L. Zerfas, Andres F. Salazar-Chaparro, Darci J. Trader

Institution: Purdue University West Lafayette

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Purdue University Center for Cancer Research, National Cancer Institute, National Institute of General Medical Sciences