Work

Parylene C as an Insulating Polymer for Implantable Neural Interfaces: Acute Electrochemical Impedance Behaviors in Saline and Pig Brain In Vitro

Year: 2022

Type: article

Abstract: Parylene is used as encapsulating material for medical devices due to its excellent biocompatibility and insulativity. Its performance as the insulating polymer of implantable neural interfaces has been studied in electrolyte solutions and in vivo. Biological tissue in vitro, as a potential environment for characterization and application, is convenient to access in the fabrication lab of polymer and neural electrodes, but there has been little study investigating the behaviors of Parylene in the tissue in vitro. Here, we investigated the electrochemical impedance behaviors of Parylene C polymer coating both in normal saline and in a chilled pig brain in vitro by performing electrochemical impedance spectroscopy (EIS) measurements of platinum (Pt) wire neural electrodes. The electrochemical impedance at the representative frequencies is discussed, which helps to construct the equivalent circuit model. Statistical analysis of fitted parameters of the equivalent circuit model showed good reliability of Parylene C as an insulating polymer in both electrolyte models. The electrochemical impedance measured in pig brain in vitro shows marked differences from that of saline.

Source: Polymers

DOI: 10.3390/polym14153033

Authors: Yuan Zhang, Jing Zhang, Song Le, Lan Niu, Jin Tao, Jingqiu Liang, Lihua Zhang, Xiaoyang Kang

Institutions: Fudan University, State Key Laboratory of Medical Neurobiology, Frontiers Center for Brain Science of the Ministry of Education, Ji Hua Laboratory, Chinese Academy of Sciences, Changchun Institute of Optics, Fine Mechanics and Physics, State Key Laboratory of Applied Optics, Zhejiang Lab

Language: English

Topic: Neuroscience and Neural Engineering

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,513

Funders: Ji Hua Laboratory, National Natural Science Foundation of China, Fudan University, Science and Technology Commission of Shanghai Municipality, National Key Research and Development Program of China

Awards: G1301064832, G1304539524, G1305117808, G1415410481, G1503850533, G1543926861, G1614680784, G181997071, G1926475483, G1934945128, G2022062133, G2099786747, G2317978195, G231848252, G2431536558, G2457548366, G2533950751, G255160342, G269866877, G2787663095, G296198563, G3125932999, G3208788829, G3351285525, G3451584290, G3520359106, G3603046598, G3867487915, G3920411881, G3955273678, G4321700915, G4369120348, G5154848714, G5177365330, G5285269757, G5375933565, G5481929365, G5495614398, G5514114845, G552782032, G5574148142, G5665038695, G6131199608, G6242096479, G6244745179, G6265710886, G6271259443, G6300311230, G6331850339, G64899366, G6758385550, G709658499, G7223888415, G7313064630, G7551391085, G7717894756, G7865240111, G7937426765, G7997179098, G8043359214, G8260978993, G8274730919, G8299876865, G8463148140, G8494586185, G8575818762, G8712293185, G8788150448, G883461579, G8899475930, G8904538476, G929844129

OpenAlex ID: W4288081175

FWCI: 1.105

Cites: 55

Cited by: 14

Related to: 10