Work

Increased Expression and Amplification of bla KPC-2 Contributes to Resistance to Ceftazidime/Avibactam in a Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Strain

Year: 2022

Type: article

Abstract: Klebsiella pneumoniae carbapenemase (KPC) production is the most common mechanism of K. pneumoniae resistance to carbapenems in China. Currently, CAZ/AVI is considered a potential alternative therapeutic option for infections caused by these isolates.

Source: Microbiology Spectrum

DOI: 10.1128/spectrum.00955-22

Authors: Xinhui Li, Jisheng Zhang, Chengru Yang, Jie Li, Jianmin Wang, Wan Huang, Lingyi Zeng, Xushan Liang, Wenzhang Long, Xiaoli Zhang

Institutions: The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing Medical University, First Affiliated Hospital of Jiamusi University

Language: English

Topic: Antibiotic Resistance in Bacteria

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500

Funders: Chongqing Medical University, Natural Science Foundation of Chongqing

OpenAlex ID: W4288096489

FWCI: 1.16

Cites: 28

Cited by: 21

Related to: 10