Year: 2022
Type: review
Abstract: During the past 15 years, a plethora of innovative 3D in vitro systems has been developed. They offer the possibility of identifying crucial cellular and molecular contributors to the disease by permitting manipulation of each in isolation. However, improvements are needed particularly with respect to the predictivity and validity of those models. The major challenge now is to identify which assay and readout combination(s) best suits the current scientific question(s). A deep understanding of the different platforms along with their pros and cons is a prerequisite to make this decision. This review aims to give an overview of the most prominent systems with a focus on applications, translational relevance and adoption drivers from an industry perspective.
Source: Drug Discovery Today
Authors: Julia Schueler, Jeffrey Borenstein, Ludoviko Buti, Meng Dong, Fatma Masmoudi, Kolin Hribar, Elizabeth Anderson, Wolfgang Sommergruber
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,820
OpenAlex ID: W4288455547