Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of nonmelanoma skin cancer
Year: 2022
Type: article
Abstract: Nonmelanoma skin cancers (NMSCs) are some of the most commonly diagnosed malignancies. In general, early-stage NMSCs have favorable outcomes; however, a small subset of patients develop resistant, advanced, or metastatic disease, or aggressive subtypes that are more challenging to treat successfully. Recently, immune checkpoint inhibitors (ICIs) have been approved by the US Food and Drug Administration (FDA) for the treatment of Merkel cell carcinoma (MCC), cutaneous squamous cell carcinoma (CSCC), and basal cell carcinoma (BCC). Although ICIs have demonstrated activity against NMSCs, the routine clinical use of these agents may be more challenging due to a number of factors including the lack of predictive biomarkers, the need to consider special patient populations, the management of toxicity, and the assessment of atypical responses. With the goal of improving patient care by providing expert guidance to the oncology community, the Society for Immunotherapy of Cancer (SITC) convened a multidisciplinary panel of experts to develop a clinical practice guideline (CPG). The expert panel drew on the published literature as well as their own clinical experience to develop recommendations for healthcare professionals on important aspects of immunotherapeutic treatment for NMSCs, including staging, biomarker testing, patient selection, therapy selection, post-treatment response evaluation and surveillance, and patient quality of life (QOL) considerations, among others. The evidence- and consensus-based recommendations in this CPG are intended to provide guidance to cancer care professionals treating patients with NMSCs.
Authors: Ann W Silk, Christopher A Barker, Shailender Bhatia, Kathryn B Bollin, Sunandana Chandra, Zeynep Eroglu, Brian R Gastman, Kari L Kendra, Harriet Kluger, Evan J Lipson, Kathleen Madden, David M Miller, Paul Nghiem, Anna C Pavlick, Igor Puzanov, Guilherme Rabinowits, Emily S Ruiz, Vernon K Sondak, Edward A Tavss, Michael T Tetzlaff, Isaac Brownell
Institutions: Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center, University of Washington, Scripps MD Anderson Cancer Center, Northwestern University, Moffitt Cancer Center, Cleveland Clinic, The Ohio State University, Yale Cancer Center, Yale University, Johns Hopkins University, Johns Hopkins Medicine, Sidney Kimmel Comprehensive Cancer Center, NYU Langone’s Laura and Isaac Perlmutter Cancer Center, New York University, Massachusetts General Hospital, Weill Cornell Medicine, Roswell Park Comprehensive Cancer Center, Baptist Hospital of Miami, Baptist Health South Florida, Brigham and Women's Hospital, University of California, San Francisco, National Institutes of Health
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,490
Awards: G1044130170, G1470381490
OpenAlex ID: W4288456936