Wireless electrochemical measurement of kanamycin in whole blood v1
Year: 2019
Type: preprint
Abstract: This work evaluates the life-time of the structural-switching aptamer sensors in the whole blood using in vitro blood circulation setup as the first step toward implantable usage. The device consists of a 3-electrode sensing probe with the tip of the working electrode (WE) functionalized with the antibiotics aptamers. Square-wave voltammetry (SWV) is used to continuously track both the signal peak and the background current at 5 sec temporal resolution. The sensing probe features a diameter of 800um and is inserted through a 18G catheter. Two samples of whole blood (EDTA treated), spiked with either 500uM kanamycin or SSC 1x (salin sodium citrate) buffer, are alternated toward the sensor to evaluate the degradation of the aptamer sensivitiy and the degree of drift.
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4288631327