Work

Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications

Year: 2022

Type: review

Abstract: Calcium ion (Ca 2+ ) is a ubiquitous and versatile signaling molecule controlling a wide variety of cellular processes, such as proliferation, cell death, migration, and immune response, all fundamental processes essential for the establishment of cancer. In recent decades, the loss of Ca 2+ homeostasis has been considered an important driving force in the initiation and progression of malignant diseases. The primary intracellular Ca 2+ store, the endoplasmic reticulum (ER), plays an essential role in maintaining Ca 2+ homeostasis by coordinating with other organelles and the plasma membrane. Here, we discuss the dysregulation of ER-centered Ca 2+ homeostasis in cancer, summarize Ca 2+ -based anticancer therapeutics, and highlight the significance of furthering our understanding of Ca 2+ homeostasis regulation in cancer.

Source: Trends in Cell Biology

DOI: 10.1016/j.tcb.2022.07.004

Authors: Shanliang Zheng, Xingwen Wang, Dong Zhao, Hao Liu, Ying Hu

Institution: Harbin Institute of Technology

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $6,700