Work

An aco-2::gfp knock-in enables the monitoring of mitochondrial morphology throughout C. elegans lifespan.

Year: 2022

Type: article

Abstract: strain displays the prototypic changes in mitochondrial morphology known to occur during aging and upon paraquat (PQ) induced mitochondrial stress. We also provide evidence that the ACO-2::GFP reporter can serve as a superior means for tracking mitochondrial morphology than conventional MitoTracker dyes-especially in aged-worms.

Source: PubMed Central

DOI: 10.17912/micropub.biology.000599

Authors: David V. Begelman, Georgia Woods, Dipa Bhaumik, Suzanne Angeli, Anna C Foulger, Mark Lucanic, Jianfeng Lan, Julie K. Andersen, Gordon J. Lithgow

Institutions: Buck Institute for Research on Aging, University of Maine, Guilin Medical University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute on Aging

Awards: G588507477, A temporal bioenergetic, metabolomics, and proteomic map of Alzheimer's disease in invertebrate models

OpenAlex ID: W4288785136

FWCI: 0.482

Cites: 18

Cited by: 6

Related to: 10