Work

Monoclonal antibodies to lipoarabinomannan/arabinomannan – characteristics and implications for tuberculosis research and diagnostics

Year: 2022

Type: review

Abstract: Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.

Source: Trends in Microbiology

DOI: 10.1016/j.tim.2022.07.001

Authors: Devin T. Corrigan, Elise Ishida, Delphi Chatterjee, Todd L. Lowary, Jacqueline M. Achkar

Institutions: Albert Einstein College of Medicine, Colorado State University, National Taiwan University, Institute of Biological Chemistry, Academia Sinica, Academia Sinica

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $6,700