Year: 2019
Type: article
Abstract: Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consistent with extensive balancing and positive selection, NLRs are encoded by one of the most variable gene families in plants, but the true extent of intraspecific NLR diversity has been unclear. Here, we define a nearly complete species-wide pan-NLRome in Arabidopsis thaliana based on sequence enrichment and long-read sequencing. The pan-NLRome largely saturates with approximately 40 well-chosen wild strains, with half of the pan-NLRome being present in most accessions. We chart NLR architectural diversity, identify new architectures, and quantify selective forces that act on specific NLRs and NLR domains. Our study provides a blueprint for defining pan-NLRomes.
Source: Cell
Institutions: Max Planck Institute for Developmental Biology, University of North Carolina at Chapel Hill, Howard Hughes Medical Institute, Center for Research in Agricultural Genomics, University of East Anglia, Norwich Research Park, Sainsbury Laboratory, Colorado State University, University of Bath
Language: English
Subfield: Plant Science
Domain: Life Sciences
SDG: Zero hunger
Open Access status: hybrid
Estimated APC paid: $5,200
Awards: Defining and deploying Rpi gene diversity in S. americanum to control late blight in potato, An enduring pipeline to identify and utilize durable late blight disease resistance in potato, G1643636722, Gene-for-gene coevolution between Albugo candida and Arabidopsis; mining non-host resistance genes for white rust control in Brassicaceae crops, Employing a Breakthrough Technology to Uncover the Diversity of Immune Receptors in Plants, Structure-Function Analyses of Plant NLR receptors, G6658962124, G7107907044, Controlling important diseases in potato by cloning functional NB-LRR-type resistance genes, G8618019430, G909035405
OpenAlex ID: W2969924257